You might have observed when there is a cut in your finger or if hurt yourself, the wound does not continue to bleed for a long time. Usually, the blood stops flowing after some time. Do you know why?
This is because of blood which exhibits coagulation property.
Blood coagulates in response to injury or trauma. This property is highly desired to prevent excessive loss of blood from the body and heal the wound quickly.
Coagulation deals with the action of platelet cells and clotting proteins. These proteins These proteins are found in the blood plasma and on the surfaces of certain vascular, or blood vessel and cells.
After a few days of injury, you might have observed a dark brownish scum found at the site of the cut. This is exactly the clot or coagulum formed. The coagulum is formed of main networks of thread called fibrin in which dead and damaged formed elements of blood are trapped.
Whenever there is an injury or cut, then the biomolecules present in the blood which are in the in-active state get to play a vital role. And in the process of clotting, the blood changes from a liquid to a solid at the site of an injury.
Let us brief up the process of coagulation
1. The blood coagulation comes into play when there is an injury in the form of a cut or a wound. This tear causes bleeding.
2. To control blood loss the blood vessel narrows (called constriction), thus limiting blood flow through the vessel.
3. In response to the injury, tiny cells in the blood called platelets are activated. The platelets stick to one another and to the wound site to form a plug. The protein von Willebrand factor (VWF) helps the platelets stick to each other and to the blood vessel wall.
4. Next, clotting factor proteins trigger the production of fibrin, a strong, strand-like substance that forms a fibrin clot, a mesh-like net that keeps the plug firm and stable. Over the next several days to weeks, the clot strengthens and then dissolves as the wounded blood vessel wall heals.
And if there is an abnormality in any part of the process, it can lead to dangerous complications such as severe blood loss. Commonly, people with clotting disorders are closely monitored to prevent injuries and bleeding. Blood clotting is a crucial process that can help prevent blood loss due to injury.
Drafted by Nagama Nadaf