Tooth- decay? Grow a new tooth using stem cell in the near future

STUDY OF INTEREST

Tooth-decay 

Now an international team of researchers has found a potential novel solution to tooth decay.

DETAIL STUDY

Stem cells could hold the key to wound healing, via their ability to develop into any kind of specialised cell types – including cells in teeth. Hence no more painful tooth decay.

Taking care of personal hygiene is important for both health and social reasons. It benefits your health and impacts positively the lives around you. Personal hygiene includes your clean hands, head, body and not to forget the tooth. Taking at-most care of your mouth, teeth and gums is a worthy goal. It is a fact that good oral and dental hygiene prevents bad odour, tooth decay and gum disease.

When dental hygiene is ignored it leads to medical disorders like gum disease, it may also include risk of serious health problems like heart attack, stroke and poorly controlled diabetes and preterm labour.

Tooth pain is severe pain. And cavity in a tooth is a riddle for the dentist. To save the tooth, they need to further drill more and ultimate leads to damage. The Solution to dental cavity currently by the dentist is to excavate the decay and the surrounding area and later filling the resulting crater with a durable surrogate material like metal, plastic or glass cement.

To avoid all this dental mess I recommend  you

Oral B Pro 600 Cross Action Electric Rechargeable Toothbrush on Amazon

Drilling holes into teeth and later patching them up with synthetic filers is a tedious job.  Researchers are also discovering a more appropriate solution to tooth decay.

So let us see what is the recent advancement carried out in this field. 

Recently, researchers discovered a new way to replace the damaged teeth. The innovative method is far from drilling hoes and patching up. Here the researchers could coax out pearly white tooth to grow themselves.

Exactly, the researchers regenerated tooth in mice. Suppose this is brought in practice then it would be one of the important advances in history.  According to researchers stem cells can be manipulated into becoming virtually any type of tissues and cell. That is why I consider stem cells to be the gems in the medical field. To get more information on stem cells you can read the below article.

Related: The Gems-Stem cells

Why do you think you have a toothache?

Our teeth are prone to damage over time. Most of the damage they endure are due to our major negligency of not taking proper dental hygiene care. Others are due to injuries due to everyday wear and tear as well as the microbial activities in the mouth. After eating when we don’t rinse our mouth properly, these tiny microbes coat the surface of each tooth and feed on meal remnants. And as they continue enjoying the particles of food in your tooth, some microbes produce and secrete acid as a by-product. Which ultimately leads to enamel degradation which is the hard outer layer of the tooth.

You may wonder why not teeth repair themselves just like skin? The answer is they repair minor mishaps themselves. But when our teeth are uncleaned for too long, the acid produces by bacteria slowly eats through enamel and begin to dissolve the underlying layer of dense, bony tissue called dentin. Suppose dentin is injured, then stem cells in the innermost layer of the tooth which is the dental pulp morph into cells called odontoblasts. These cells can secrete new tissues. If  the injury is too major or deep, that fresh dentin won’t help to  restore the tooth which often results in a cavity.

 Research Creditors

The Study was conducted by a team of researchers including those from the Biotechnology Center of the TU Dresden (BIOTEC). The research was published titled as “Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation,” in the journal Nature Communications by the study leader Dr Bing Hu of the Peninsula Dental School of the University of Plymouth. According to this team, stem cells could be used for several forms of tissue engineering including tooth repair. Researchers coaxed these stem cells to become teeth. This technique could relieve many patients. 

RESEARCHER’S STATEMENTS

 

“The discovery of this new population of stromal cells was very exciting and has enormous potential in regenerative medicine.”

-Dr. Denis Corbeil

How was the experiment carried out?

The team carried out their experiments on mice incisors. According to experts “mouse incisors undergo lifelong growth as a result of epithelial–mesenchymal interactions. Each mouse incisor tooth has a persisting epithelial SC-TAC zone at its posterior end of the tooth, named cervical loop (CL) based on the epithelial structure.”

Also, the team noticed that the mice incisor teeth contained mesenchymal stromal cells which grew consistently. And Dentin is due to these mesenchymal stromal cells, which covers the tooth completely. Suppose these stem cells or stromal cells are activated, then they send  signal to their original cells to produce more number of cells. This process is accompanied by the use of a gene called Dlk1.

According to researchers, two types of cells promote regeneration-

1. Tissue-specific mesenchymal stem cells (MSCs)

2.  Mesenchymal transit-amplifying cells (MTACs)

Gene D1k1 maintained the balance of cells and the differentiation of the different cells of their lineage between these two types of cells.  The Dlk1 also stimulated the epithelial stem cells and primes them for self-renewal. Hence according to the paper gene Dlk1 activation is the key to activation of the stem cells to produce the desired cells that would help in regeneration and wound healing in the mice models. 

Conclusion

If this study is carried out further and after human trials, if it is accepted where there is no  complication seen then this study could prove to be the ultimate foundation in tooth repair. Also, it will help patients with teeth decay, tooth breakage in case of injuries etc. 

It is important to understand oral health — and its connection to your overall health. A healthy mouth may help you to avoid medical disorders. Good oral hygiene keeps getting you stronger.

Tips to keep your teeth healthy 

It is generally recommended to brush at least twice a day. Brushing before bed gets rid of the germs and plaque that accumulate throughout the day, knowing this still we neglect to brush during the night. Plaque can also build up on your tongue, hence gently brush your tongue every time you brush your teeth. Also, treat flossing as important as brushing.

Shop  for toothbrushes online.

Go for dental flossing here.

ARTICLE SOURCE 

 1. Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation |Jemma Victoria Walker, Heng Zhuang, Bing Hu. Nature Communications volume 10, Article number: 3596 (2019).

 

Drafted by Nagama Nadaf
 A technophile who is crazy about technology and passionate about blogging. 
I care by sharing recent advancements in technology and try to reach out to the minds of people

Nagama Nadaf
Blogger

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