Bio-glue holds on to post traumatic bleeding in seconds

Bio-glue act as a wonder wound healer. It is  successfully tested on animal hearts. This “matrix gel” could end a major cause of preventable death.

STUDY OF INTEREST

 Bio-Glue

Bio-glue act as a wonder wound healer. It is  successfully tested on animal hearts. This “matrix gel” could end a major cause of preventable death.

DETAIL STUDY 

Bio-glue could save people from bleeding out- Thanks to chinese researchers. 

Chinese researchers are taking Medical Science to a whole new level. Recently a new innovative bio-glue was invented that promises to save many life.

When an accident strikes in most of the cases, post-traumatic bleeding causes more harm than the injury itself. According to the National Institutes of Health (NIH), deaths can be prevented among trauma patients if post-traumatic bleeding can be controlled.

Currently, the solution to withhold the bleeding is to suture or employ hemostatic agents, they do help, but are inefficient. Because of weak adhesion to  wet mobile tissues, they poorly control haemorrhaging from traumatic cardiac wounds. Hence the solution “bio-glue”, lies with these Chinese researchers where they have demonstrated in animal experiments that a light-activated adhesive gel can rapidly seal wounds to arteries and the heart, which could have potential applications in surgery in the future.

What is bio-glue?

A team led by researchers from Zhejiang University and East China University Of Science And Technology designed Bio-glue.

Bio-glue is a gel composed of a network of proteins and other molecules, which mimics the matrix composition of human connective tissues also known as extracellular matrix(ECM). We know that cell is the basic component and all animals are made out of cells. Collagen is said to be the most abundant protein in the human body, and it is essential in building blocks of the body’s connective tissues. Collagen is found within ECM. Also, muscles, joints and even teeth all depend on the ECM to keep things intact.

How does Bio-glue work?

 

When this bio-glue is placed on an open wound it is then activated through UV-light. On exposure to UV radiation bio-glue rapidly morphs into a non-toxic hydrogel, this thick and solidified gel adheres to wound, preventing blood from flowing out. The whole process is of about 30 seconds and the seal generated is robust enough which can withstand up to 290-mmHg blood pressure- which is quite higher than normal.

RESEARCHER’S STATEMENT

“This highly efficient gel material can be injected, and has the potential to be used for surgical hemostasis and wound fast sealing in use cases like open surgery and minimally invasive endoscopic surgery”.

– Yi Hong, one of the authors from Zhejiang University, told Xinhua.

The Experiment performed using Bio-glue 

 The adhesive sealant Bio glue is not yet tested on human organs, but in  preliminary animal experiments, scientists showed that their bio-glue was capable to seal wounds in animal livers.

After successfully sealing the animal liver, the next step was a demonstration using animal hearts which is considered the most difficult of surgical challenges. 

The animal heart is very similar to the animal because they share two atrium and two ventricles. The gel was tested on three animals and all the three survived and showed signs of natural healing. 

“It is the first time that high-pressure bleeding of a beating heart with 6 millimeter diameter cardiac penetration holes was rapidly stopped and the wounds were stably sealed by only using matrix gel within 20 [seconds] without suture.” 

“The hydrogel also effectively sealed the heart wound after [two] weeks, and almost no necrosis and very little inflammation were observed at the wound interface in pathology section staining, confirming the excellent biocompatibility of the matrix hydrogel,”

– Yi Hong, one of the authors from Zhejiang University

 Future aspect

Tissue engineer and one of the study’s authors, Hongwei Ouyang told Science Alert that the product could be ready for use on people in the next 3 to 5 years.

If such bio-glue comes in the market within this time than it would create happy surgical endings. Also, it would be a good-bye to those long surgical procedures of needles, scissors  and band-aids.

ARTICLE SOURCE 

 

1. Yi Hong, Feifei Zhou, Yujie Hua, Xianzhu Zhang, Chengyao Ni, Dihao Pan, Yiqing Zhang, Deming Jiang, Long Yang, Qiuning Lin, Yiwei Zou, Dongsheng Yu, David E. Arnot, Xiaohui Zou, Linyong Zhu, Shufang Zhang & Hongwei Ouyang. A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds

2. Science alert

Drafted by Nagama Nadaf
 A technophile who is crazy about technology and passionate about blogging. 
I care by sharing recent advancements in technology and try to reach out to the minds of people

Nagama Nadaf
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